Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease.
Identifieur interne : 000190 ( Main/Exploration ); précédent : 000189; suivant : 000191Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease.
Auteurs : T Celeste Napier [États-Unis] ; Jean-Christophe Corvol ; Anthony A. Grace ; Jamie D. Roitman ; James Rowe ; Valerie Voon ; Antonio P. StrafellaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Brain (drug effects), Brain (pathology), Disease Models, Animal, Dopamine Agonists (therapeutic use), Humans, Impulse Control Disorders (complications), Impulse Control Disorders (diagnosis), Impulse Control Disorders (drug therapy), Impulse Control Disorders (genetics), Impulsive Behavior (drug effects), Impulsive Behavior (physiology), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (genetics).
- MESH :
- chemical , therapeutic use : Dopamine Agonists.
- complications : Impulse Control Disorders, Parkinson Disease.
- diagnosis : Impulse Control Disorders.
- drug effects : Brain, Impulsive Behavior.
- drug therapy : Impulse Control Disorders, Parkinson Disease.
- genetics : Impulse Control Disorders, Parkinson Disease.
- pathology : Brain.
- physiology : Impulsive Behavior.
- Animals, Disease Models, Animal, Humans.
Abstract
Patients with Parkinson's disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates has occurred. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings.
DOI: 10.1002/mds.26068
PubMed: 25476402
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates has occurred. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings.</div>
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<name sortKey="Roitman, Jamie D" sort="Roitman, Jamie D" uniqKey="Roitman J" first="Jamie D" last="Roitman">Jamie D. Roitman</name>
<name sortKey="Rowe, James" sort="Rowe, James" uniqKey="Rowe J" first="James" last="Rowe">James Rowe</name>
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<country name="États-Unis"><region name="Illinois"><name sortKey="Napier, T Celeste" sort="Napier, T Celeste" uniqKey="Napier T" first="T Celeste" last="Napier">T Celeste Napier</name>
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